Aging and local chronic inflammation are established risk factors for epithelial
tumorigenesis. These risk factors can act individually and/or synergistically to increase the
incidence of age-related carcinomas. The basis for this co-stimulatory response has not yet
been defined, nor have the feedback mechanisms that are responsible for this synergism.
This review provides insight into the age-stimulated dysregulation of coordination of
feedbacks in oxygen-, heme-, and proteolysis-dependent metabolic pathways caused by …