Mapping of a new target region of allelic loss at 21q22 in primary gastric cancers
WS Park, RR Oh, JY Park, NJ Yoo, SH Lee, MS Shin… - Cancer letters, 2000 - Elsevier
Cancer letters, 2000•Elsevier
To determine the minimal region of deletion on 21q22 in gastric cancer, we performed a
high-density loss of heterozygosity (LOH) study with eight polymorphic microsatellite
markers. Among the 43 tumors examined, 20 (50%) of 40 informative carcinomas showed
LOH at one or more loci. The peak LOH frequency was identified at D21S1820 (34.2%) in
21q22. 3. This data suggests that this locus might harbor a new tumor suppressor gene in an
area< 0.332 Mb in physical map distance defined by D21S1820 and D21S49. Thus, we …
high-density loss of heterozygosity (LOH) study with eight polymorphic microsatellite
markers. Among the 43 tumors examined, 20 (50%) of 40 informative carcinomas showed
LOH at one or more loci. The peak LOH frequency was identified at D21S1820 (34.2%) in
21q22. 3. This data suggests that this locus might harbor a new tumor suppressor gene in an
area< 0.332 Mb in physical map distance defined by D21S1820 and D21S49. Thus, we …
To determine the minimal region of deletion on 21q22 in gastric cancer, we performed a high-density loss of heterozygosity (LOH) study with eight polymorphic microsatellite markers. Among the 43 tumors examined, 20 (50%) of 40 informative carcinomas showed LOH at one or more loci. The peak LOH frequency was identified at D21S1820 (34.2%) in 21q22.3. This data suggests that this locus might harbor a new tumor suppressor gene in an area <0.332 Mb in physical map distance defined by D21S1820 and D21S49. Thus, we speculate that trefoil factor family 1 (TFF1), located in this narrow region, might be the most probable candidate gene involved in gastric cancer carcinogenesis.
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