[HTML][HTML] Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties
GF Kelso, CM Porteous, CV Coulter, G Hughes… - Journal of Biological …, 2001 - ASBMB
With the recognition of the central role of mitochondria in apoptosis, there is a need to
develop specific tools to manipulate mitochondrial function within cells. Here we report on
the development of a novel antioxidant that selectively blocks mitochondrial oxidative
damage, enabling the roles of mitochondrial oxidative stress in different types of cell death to
be inferred. This antioxidant, named mitoQ, is a ubiquinone derivative targeted to
mitochondria by covalent attachment to a lipophilic triphenylphosphonium cation through an …
develop specific tools to manipulate mitochondrial function within cells. Here we report on
the development of a novel antioxidant that selectively blocks mitochondrial oxidative
damage, enabling the roles of mitochondrial oxidative stress in different types of cell death to
be inferred. This antioxidant, named mitoQ, is a ubiquinone derivative targeted to
mitochondria by covalent attachment to a lipophilic triphenylphosphonium cation through an …