[PDF][PDF] B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization

V Angeli, F Ginhoux, J Llodrą, L Quemeneur… - Immunity, 2006 - cell.com
V Angeli, F Ginhoux, J Llodrą, L Quemeneur, PS Frenette, M Skobe, R Jessberger, M Merad
Immunity, 2006cell.com
Dendritic cell (DC) migration from the periphery to lymph nodes is regulated by the pattern of
genes expressed by DCs themselves and by signals within the surrounding peripheral
environment. Here, we report that DC mobilization can also be regulated by signals initiated
within the downstream lymph nodes, particularly when lymph nodes enlarge as a
consequence of immunization. Lymph node B lymphocytes orchestrate expansion of the
lymphatic network within the immunized lymph node. This expanded network in turn …
Summary
Dendritic cell (DC) migration from the periphery to lymph nodes is regulated by the pattern of genes expressed by DCs themselves and by signals within the surrounding peripheral environment. Here, we report that DC mobilization can also be regulated by signals initiated within the downstream lymph nodes, particularly when lymph nodes enlarge as a consequence of immunization. Lymph node B lymphocytes orchestrate expansion of the lymphatic network within the immunized lymph node. This expanded network in turn supports increased DC migration from the periphery. These results reveal unique relationships between B cells, lymphatic vessels, and migratory DCs. Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination.
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