Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice

K Miyawaki, Y Yamada, H Yano… - Proceedings of the …, 1999 - National Acad Sciences
K Miyawaki, Y Yamada, H Yano, H Niwa, N Ban, Y Ihara, A Kubota, S Fujimoto, M Kajikawa…
Proceedings of the National Academy of Sciences, 1999National Acad Sciences
Mice with a targeted mutation of the gastric inhibitory polypeptide (GIP) receptor gene
(GIPR) were generated to determine the role of GIP as a mediator of signals from the gut to
pancreatic β cells. GIPR−/− mice have higher blood glucose levels with impaired initial
insulin response after oral glucose load. Although blood glucose levels after meal ingestion
are not increased by high-fat diet in GIPR+/+ mice because of compensatory higher insulin
secretion, they are significantly increased in GIPR−/− mice because of the lack of such …
Mice with a targeted mutation of the gastric inhibitory polypeptide (GIP) receptor gene (GIPR) were generated to determine the role of GIP as a mediator of signals from the gut to pancreatic β cells. GIPR−/− mice have higher blood glucose levels with impaired initial insulin response after oral glucose load. Although blood glucose levels after meal ingestion are not increased by high-fat diet in GIPR+/+ mice because of compensatory higher insulin secretion, they are significantly increased in GIPR−/− mice because of the lack of such enhancement. Accordingly, early insulin secretion mediated by GIP determines glucose tolerance after oral glucose load in vivo, and because GIP plays an important role in the compensatory enhancement of insulin secretion produced by a high insulin demand, a defect in this entero-insular axis may contribute to the pathogenesis of diabetes.
National Acad Sciences