Nuclear factor-kappa B in intestinal protection and destruction
ME Spehlmann, L Eckmann - Current opinion in gastroenterology, 2009 - journals.lww.com
Current opinion in gastroenterology, 2009•journals.lww.com
NF-κB has multiple, often opposing functions in the intestine. Antiapoptotic actions of NF-κB
in intestinal epithelial cells dominate tissue responses to many acute inflammatory and
injurious challenges, whereas proinflammatory and cell survival functions of NF-κB in
macrophages and T cells govern chronic intestinal inflammation.
in intestinal epithelial cells dominate tissue responses to many acute inflammatory and
injurious challenges, whereas proinflammatory and cell survival functions of NF-κB in
macrophages and T cells govern chronic intestinal inflammation.
Summary
NF-κB has multiple, often opposing functions in the intestine. Antiapoptotic actions of NF-κB in intestinal epithelial cells dominate tissue responses to many acute inflammatory and injurious challenges, whereas proinflammatory and cell survival functions of NF-κB in macrophages and T cells govern chronic intestinal inflammation.
Lippincott Williams & Wilkins