Chemokines and chemokine receptors encoded by cytomegaloviruses
PS Beisser, H Lavreysen, CA Bruggeman… - Human Cytomegalovirus, 2008 - Springer
PS Beisser, H Lavreysen, CA Bruggeman, C Vink
Human Cytomegalovirus, 2008•SpringerCMVs carry several genes that are homologous to genes of the host organism. These
include genes homologous to those encoding chemokines (CKs) and G protein-coupled
receptors (GPCRs). It is generally assumed that these CMV genes were hijacked from the
host genome during the long co-evolution of virus and host. In light of the important function
of the CK and GPCR families in the normal physiology of the host, it has previously been
hypothesized that the CMV homologs of these proteins, CMV vCKs and vGPCRs, may also …
include genes homologous to those encoding chemokines (CKs) and G protein-coupled
receptors (GPCRs). It is generally assumed that these CMV genes were hijacked from the
host genome during the long co-evolution of virus and host. In light of the important function
of the CK and GPCR families in the normal physiology of the host, it has previously been
hypothesized that the CMV homologs of these proteins, CMV vCKs and vGPCRs, may also …
Abstract
CMVs carry several genes that are homologous to genes of the host organism. These include genes homologous to those encoding chemokines (CKs) and G protein-coupled receptors (GPCRs). It is generally assumed that these CMV genes were hijacked from the host genome during the long co-evolution of virus and host. In light of the important function of the CK and GPCR families in the normal physiology of the host, it has previously been hypothesized that the CMV homologs of these proteins, CMV vCKs and vGPCRs, may also have a significant impact on this physiology, such that lifelong maintenance and/or replication of the virus within the infected host is guaranteed. In addition, several of these homologs were reported to have a major impact in the pathogenesis of infection. In this review, the current state of knowledge on the CMV vCKs and vGPCRs will be discussed.
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