15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size)
DG Tang, B Bhatia, S Tang… - Prostaglandins & other …, 2007 - Elsevier
15-Lipoxygenase 2 (15-LOX2) is the major mammalian lipoxygenase expressed in normal
human adult prostate and its expression is decreased or lost in high-grade prostate
intraepithelial neoplasia (HGPIN) and prostate cancer (PCa). Our recent work has
demonstrated that (1) 15-LOX2 has multiple alternatively spliced isoforms and is a negative
cell-cycle regulator in normal human prostate (NHP) epithelial cells;(2) 15-LOX2 in NHP
cells is positively regulated by Sp1 and negatively regulated by Sp3;(3) 15-LOX2 in NHP …
human adult prostate and its expression is decreased or lost in high-grade prostate
intraepithelial neoplasia (HGPIN) and prostate cancer (PCa). Our recent work has
demonstrated that (1) 15-LOX2 has multiple alternatively spliced isoforms and is a negative
cell-cycle regulator in normal human prostate (NHP) epithelial cells;(2) 15-LOX2 in NHP
cells is positively regulated by Sp1 and negatively regulated by Sp3;(3) 15-LOX2 in NHP …