Lipoxygenase pathways as mediators of early inflammatory events in atherosclerosis
CD Funk - Arteriosclerosis, thrombosis, and vascular biology, 2006 - Am Heart Assoc
Arteriosclerosis, thrombosis, and vascular biology, 2006•Am Heart Assoc
Oxidative modification of low density lipoproteins has been a leading hypothesis in
atherogenesis, and throughout the 1990's there was intense interest in the discovery of
pathways leading to this modification. 1, 2 In a commentary to an article dealing with 12/15-
lipoxygenase gene disruption in the atherosclerotic apolipoprotein E (apoE)-deficient mouse
model in 1999, Daniel Steinberg declared “at last direct evidence that lipoxygenases play a
role in atherosclerosis.” 3, 4 Since this article seven years ago, the lipoxygenase pathway …
atherogenesis, and throughout the 1990's there was intense interest in the discovery of
pathways leading to this modification. 1, 2 In a commentary to an article dealing with 12/15-
lipoxygenase gene disruption in the atherosclerotic apolipoprotein E (apoE)-deficient mouse
model in 1999, Daniel Steinberg declared “at last direct evidence that lipoxygenases play a
role in atherosclerosis.” 3, 4 Since this article seven years ago, the lipoxygenase pathway …
Oxidative modification of low density lipoproteins has been a leading hypothesis in atherogenesis, and throughout the 1990’s there was intense interest in the discovery of pathways leading to this modification. 1, 2 In a commentary to an article dealing with 12/15-lipoxygenase gene disruption in the atherosclerotic apolipoprotein E (apoE)-deficient mouse model in 1999, Daniel Steinberg declared “at last direct evidence that lipoxygenases play a role in atherosclerosis.” 3, 4 Since this article seven years ago, the lipoxygenase pathway involvement in atherogenesis has become rather more complicated.
Am Heart Assoc