Mouse models of 22q11 deletion syndrome
R Paylor, E Lindsay - Biological psychiatry, 2006 - Elsevier
22q11 deletion syndrome (22q11DS) is caused by an interstitial chromosomal microdeletion
that encompasses about 40 genes. It is the most common of the microdeletion syndromes.
The clinical phenotype, which is complex and variable, includes specific congenital defects
of the cardiovascular system, craniofacies, and immune system. In early childhood, patients
manifest cognitive impairment, behavioral disorders, and delays in motor development and
language acquisition. Adult patients have a high risk for developing serious psychiatric …
that encompasses about 40 genes. It is the most common of the microdeletion syndromes.
The clinical phenotype, which is complex and variable, includes specific congenital defects
of the cardiovascular system, craniofacies, and immune system. In early childhood, patients
manifest cognitive impairment, behavioral disorders, and delays in motor development and
language acquisition. Adult patients have a high risk for developing serious psychiatric …