Consequences of growth hormone (GH) overexpression and GH resistance

A Bartke, V Chandrashekar, B Bailey, D Zaczek… - Neuropeptides, 2002 - Elsevier
Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance
provided novel animal models for study of the somatotropic axis and for identifying GH
actions that may be relevant to its current and contemplated use in medicine and agriculture.
Studies of phenotypic characteristics of these animals revealed previously unsuspected
actions of GH and IGF-I on neuroendocrine functions related to reproduction and to the
release of “stress hormones”(glucocorticoids and prolactin). These studies also provided …