Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care
E Weitzberg, M Hezel, JO Lundberg… - The Journal of the …, 2010 - pubs.asahq.org
The gaseous radical nitric oxide is involved in numerous physiologic and pathophysiological
events important in anesthesiology and intensive care. Nitric oxide is endogenously
generated from the amino acid l-arginine and molecular oxygen in reactions catalyzed by
complex nitric oxide synthases. Recently, an alternative pathway for nitric oxide generation
was discovered, wherein the inorganic anions nitrate (NO3) and nitrite (NO2), most often
considered inert end products from nitric oxide generation, can be reduced back to nitric …
events important in anesthesiology and intensive care. Nitric oxide is endogenously
generated from the amino acid l-arginine and molecular oxygen in reactions catalyzed by
complex nitric oxide synthases. Recently, an alternative pathway for nitric oxide generation
was discovered, wherein the inorganic anions nitrate (NO3) and nitrite (NO2), most often
considered inert end products from nitric oxide generation, can be reduced back to nitric …