[HTML][HTML] Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK …
L Du, CS Lyle, TB Obey, WA Gaarde, JA Muir… - Journal of Biological …, 2004 - ASBMB
The c-Jun NH 2-terminal kinase (JNK) subgroup of mitogen-activated protein kinases has
been implicated largely in stress responses, but an increasing body of evidence has
suggested that JNK also plays a role in cell proliferation and survival. We examined the
effect of JNK inhibition, using either SP600125 or specific antisense oligonucleotides, on
cell proliferation and cell cycle progression. SP600125 was selective for JNK in vitro and in
vivo versus other kinases tested including ERK, p38, cyclin-dependent protein kinase 1 …
been implicated largely in stress responses, but an increasing body of evidence has
suggested that JNK also plays a role in cell proliferation and survival. We examined the
effect of JNK inhibition, using either SP600125 or specific antisense oligonucleotides, on
cell proliferation and cell cycle progression. SP600125 was selective for JNK in vitro and in
vivo versus other kinases tested including ERK, p38, cyclin-dependent protein kinase 1 …