An array of mitochondrial alterations in the hepatocytes of Long-Evans Cinnamon rats
I Sternlieb, N Quintana, I Volenberg, ML Schilsky - Hepatology, 1995 - Elsevier
In an attempt to identify the cellular targets of copper toxicity, we studied the ultrastructure of
hepatocytes in the livers of 23 Long-Evans Cinnamon (LEC) rats ranging in age from 10 to
89 weeks. The hepatic copper concentration ranged from 325 to 2,126 (mean, 930) μg/g dry
weight. Thirteen rats displayed varying degrees of jaundice at the time of killing. Numerous
nuclei were indented by cytoplasmic invaginations. Conspicuous abnormalities were
displayed by mitochondria. These included marked pleomorphism; increased or diminished …
hepatocytes in the livers of 23 Long-Evans Cinnamon (LEC) rats ranging in age from 10 to
89 weeks. The hepatic copper concentration ranged from 325 to 2,126 (mean, 930) μg/g dry
weight. Thirteen rats displayed varying degrees of jaundice at the time of killing. Numerous
nuclei were indented by cytoplasmic invaginations. Conspicuous abnormalities were
displayed by mitochondria. These included marked pleomorphism; increased or diminished …