Copper is an essential trace element for many biological processes. Its functions range from
influencing specific gene expression to serving as a cofactor or prosthetic group for several
enzymes. Intakes of copper at doses that exceed physiologic demands are normally met
with efficient homeostatic mechanisms. Ceruloplasmin, albumin, and transcuprein, and to a
lesser extent certain amino acids, are major copper-transporting constituents in circulating
plasma. After its hepatic uptake, copper may be stored within hepatocytes, secreted into …