Astrocyte activation and memory impairment in the repetitive febrile seizures model
L Yang, F Li, H Zhang, W Ge, C Mi, R Sun, C Liu - Epilepsy research, 2009 - Elsevier
Frequently repetitive febrile seizures (FRFS) in immature brain could impair long-term
memory without obvious pathological alteration. Although astrocyte activation has been
implicated in many seizure models, it has never been examined in febrile seizure models.
We investigated astrocyte activation states after FRFS in postnatal-10-day (P10) rats by
western blot and immunohistochemical analysis of GFAP and S100β, two protein markers
for activated astrocytes, at three time points (P25, P35, P45). The levels of GFAP and S100β …
memory without obvious pathological alteration. Although astrocyte activation has been
implicated in many seizure models, it has never been examined in febrile seizure models.
We investigated astrocyte activation states after FRFS in postnatal-10-day (P10) rats by
western blot and immunohistochemical analysis of GFAP and S100β, two protein markers
for activated astrocytes, at three time points (P25, P35, P45). The levels of GFAP and S100β …