Evidence of abnormal differentiation in giant cells of tuberous sclerosis
H Yamanouchi, V Jay, JT Rutka, S Takashima… - Pediatric …, 1997 - Elsevier
To characterize the giant cells in tuberous sclerosis, we examined immunoreactivity for
nestin, vimentin, microtubule-associated protein 111 (MAP1B), MAP2, neurorilament, and
glial ribrillary acidic protein (GFAP) in cortical tubers detected in brain specimens from 6
patients with tuberous sclerosis who had undergone surgical resection for treatment of
intractable epilepsy. Giant cells with a neuronal appearance,“neuron-like giant cells,” had a
round centrally-placed nucleus with a single, prominent nucleolus, and Nissl substance was …
nestin, vimentin, microtubule-associated protein 111 (MAP1B), MAP2, neurorilament, and
glial ribrillary acidic protein (GFAP) in cortical tubers detected in brain specimens from 6
patients with tuberous sclerosis who had undergone surgical resection for treatment of
intractable epilepsy. Giant cells with a neuronal appearance,“neuron-like giant cells,” had a
round centrally-placed nucleus with a single, prominent nucleolus, and Nissl substance was …