Enhanced tenascin expression associated with reactive astrocytes in human optic nerve heads with primary open angle glaucoma
JDO PENA, HJ VARELA, CS RICARD… - Experimental eye …, 1999 - Elsevier
Tenascin is a large extracellular matrix glycoprotein expressed in neural and non-neural
tissues. In the central nervous system, tenascin is synthesized by astrocytes during
development and wound healing, forming barriers and affecting neurite outgrowth. In this
study we examined tenascin expression in optic nerve heads of normal and glaucomatous
eyes and found that there is upregulation of tenascin mRNA and protein in reactive
astrocytes from human glaucomatous optic nerve heads compared to normal age-matched …
tissues. In the central nervous system, tenascin is synthesized by astrocytes during
development and wound healing, forming barriers and affecting neurite outgrowth. In this
study we examined tenascin expression in optic nerve heads of normal and glaucomatous
eyes and found that there is upregulation of tenascin mRNA and protein in reactive
astrocytes from human glaucomatous optic nerve heads compared to normal age-matched …