Melanoma Progression Despite Infiltration by In Vivo-primed TRP-2–specific T Cells
V Singh, Q Ji, L Feigenbaum, RM Leighty… - Journal of …, 2009 - journals.lww.com
Many antigens recognized by tumor-reactive cytotoxic CD8+ T cells are self-antigens.
Tyrosinase-related protein 2 (TRP-2) is a melanogenic enzyme expressed by both
melanocytes and melanomas that is reported to be a candidate melanoma rejection antigen.
To study the role of self-reactive CD8+ T cells in tumor immunity and autoimmunity, we
generated mice that bear a T-cell receptor transgene (TCR Tg) specific for the TRP-2 (180-
188) epitope. TRP-2 TCR Tg mice did not spontaneously develop depigmentation despite …
Tyrosinase-related protein 2 (TRP-2) is a melanogenic enzyme expressed by both
melanocytes and melanomas that is reported to be a candidate melanoma rejection antigen.
To study the role of self-reactive CD8+ T cells in tumor immunity and autoimmunity, we
generated mice that bear a T-cell receptor transgene (TCR Tg) specific for the TRP-2 (180-
188) epitope. TRP-2 TCR Tg mice did not spontaneously develop depigmentation despite …