[HTML][HTML] Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors
K Takahasi, H Kumeta, N Tsuduki, R Narita… - Journal of Biological …, 2009 - ASBMB
The RIG-I like receptor (RLR) comprises three homologues: RIG-I (retinoic acid-inducible
gene I), MDA5 (melanoma differentiation-associated gene 5), and LGP2 (laboratory of
genetics and physiology 2). Each RLR senses different viral infections by recognizing
replicating viral RNA in the cytoplasm. The RLR contains a conserved C-terminal domain
(CTD), which is responsible for the binding specificity to the viral RNAs, including double-
stranded RNA (dsRNA) and 5′-triphosphated single-stranded RNA (5′ ppp-ssRNA) …
gene I), MDA5 (melanoma differentiation-associated gene 5), and LGP2 (laboratory of
genetics and physiology 2). Each RLR senses different viral infections by recognizing
replicating viral RNA in the cytoplasm. The RLR contains a conserved C-terminal domain
(CTD), which is responsible for the binding specificity to the viral RNAs, including double-
stranded RNA (dsRNA) and 5′-triphosphated single-stranded RNA (5′ ppp-ssRNA) …