The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

F Grignani, PF Ferrucci, U Testa, G Talamo, M Fagioli… - Cell, 1993 - cell.com
F Grignani, PF Ferrucci, U Testa, G Talamo, M Fagioli, M Alcalay, A Mencarelli, F Grignani…
Cell, 1993cell.com
Acute promyelocytic leukemia is a clonal expansion of hematopoietic precursors blocked at
the promyelocytic stage. The differentiation block can be reversed by retinoic acid, which
induces blast maturation both in vitro and in vivo. Acute promyelocytic leukemia is
characterized by a 15; 17 chromosome translocation with breakpoints within the retinoic acid
a receptor
Summary
Acute promyelocytic leukemia is a clonal expansion of hematopoietic precursors blocked at the promyelocytic stage. The differentiation block can be reversed by retinoic acid, which induces blast maturation both in vitro and in vivo. Acute promyelocytic leukemia is characterized by a 15; 17 chromosome translocation with breakpoints within the retinoic acid a receptor
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