[HTML][HTML] Mouse jagged1 physically interacts with notch2 and other notch receptors: assessment by quantitative methods
K Shimizu, S Chiba, K Kumano, N Hosoya… - Journal of Biological …, 1999 - ASBMB
The Delta/Serrate/LAG-2 (DSL) domain containing proteins are considered to be ligands for
Notch receptors. However, the physical interaction between DSL proteins and Notch
receptors is poorly understood. In this study, we cloned a cDNA for mouse Jagged1
(mJagged1). To identify the receptor interacting with mJagged1 and to gain insight into its
binding characteristics, we established two experimental systems using fusion proteins
comprising various extracellular parts of mJagged1, a" cell" binding assay and a" solid …
Notch receptors. However, the physical interaction between DSL proteins and Notch
receptors is poorly understood. In this study, we cloned a cDNA for mouse Jagged1
(mJagged1). To identify the receptor interacting with mJagged1 and to gain insight into its
binding characteristics, we established two experimental systems using fusion proteins
comprising various extracellular parts of mJagged1, a" cell" binding assay and a" solid …