OBJECTIVE: The purpose of this study was to examine the functional and therapeutic
significance of pericytes in ovarian cancer vasculature. STUDY DESIGN: Tumor vessel
morphologic condition and efficacy of endothelial and pericyte targeting were examined with
the use of in vivo ovarian cancer models. The expression of platelet-derived growth factor
(PDGF) ligands and receptors was examined in endothelial, pericyte-like, and ovarian
cancer cells. RESULTS: Relative to normal vessels, tumor vasculature was characterized by …