Hormonal modulation of Δ6 and Δ5 desaturases: case of diabetes
RR Brenner - Prostaglandins, leukotrienes and essential fatty acids, 2003 - Elsevier
Animal biosynthesis of high polyunsaturated fatty acids from linoleic, α-linolenic and oleic
acids is mainly modulated by the Δ6 and Δ5 desaturases through dietary and hormonal
stimulated mechanisms. From hormones, only insulin activates both enzymes. In
experimental diabetes mellitus type-1, the depressed Δ6 desaturase is restored by insulin
stimulation of the gene expression of its mRNA. However, cAMP or cycloheximide injection
prevents this effect. The depression of Δ6 and Δ5 desaturases in diabetes is rapidly …
acids is mainly modulated by the Δ6 and Δ5 desaturases through dietary and hormonal
stimulated mechanisms. From hormones, only insulin activates both enzymes. In
experimental diabetes mellitus type-1, the depressed Δ6 desaturase is restored by insulin
stimulation of the gene expression of its mRNA. However, cAMP or cycloheximide injection
prevents this effect. The depression of Δ6 and Δ5 desaturases in diabetes is rapidly …