The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice
H Guillou, D Zadravec, PGP Martin… - Progress in lipid research, 2010 - Elsevier
In mammalian cells, elongases and desaturases play critical roles in regulating the length
and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In
the past decade, a great deal has been learnt about these enzymes and the first part of this
review summarizes our current knowledge concerning these enzymes. More recently,
several transgenic mouse models lacking either an elongase (Elovl3−/−, Elovl4−/−,
Elovl5−/−, Elovl6−/−) or a desaturase (Scd-1−/−, Scd-2−/−, Fads2−/−) have been developed …
and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In
the past decade, a great deal has been learnt about these enzymes and the first part of this
review summarizes our current knowledge concerning these enzymes. More recently,
several transgenic mouse models lacking either an elongase (Elovl3−/−, Elovl4−/−,
Elovl5−/−, Elovl6−/−) or a desaturase (Scd-1−/−, Scd-2−/−, Fads2−/−) have been developed …