[HTML][HTML] Inhibition of ultraviolet B-induced activator protein-1 (AP-1) activity by aspirin in AP-1-luciferase transgenic mice
C Huang, WY Ma, D Hanenberger, MP Cleary… - Journal of Biological …, 1997 - ASBMB
Aspirin is under consideration as a promising chemopreventative agent for human cancers.
To study the usefulness of aspirin as a chemopreventative agent for UV-induced human skin
cancer, we investigated the effect of aspirin on UVB-induced activator protein-1 (AP-1)
activity. In the JB6 cell culture system, aspirin or sodium salicylate (SA) inhibited UVB-
induced AP-1 activity in a dose-dependent manner; this inhibitory effect occurred only in
cells pretreated with aspirin or SA before UVB irradiation but not cells treated with aspirin or …
To study the usefulness of aspirin as a chemopreventative agent for UV-induced human skin
cancer, we investigated the effect of aspirin on UVB-induced activator protein-1 (AP-1)
activity. In the JB6 cell culture system, aspirin or sodium salicylate (SA) inhibited UVB-
induced AP-1 activity in a dose-dependent manner; this inhibitory effect occurred only in
cells pretreated with aspirin or SA before UVB irradiation but not cells treated with aspirin or …