Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure
CR Gomez, S Hirano, BT Cutro, S Birjandi… - Critical care …, 2007 - journals.lww.com
Objective: The aged population is at a higher risk of mortality as a result of complications of
injury or infection, such as acute lung injury. The objective of this study was to analyze
pulmonary inflammatory responses in young and aged mice after administration of
lipopolysaccharide. Design: Prospective, controlled laboratory study. Setting: Animal
resource facilities and research laboratory. Subjects: Young (2–3 months old) and aged (18–
20 months old) female BALB/c mice. Interventions: Animals received intraperitoneal injection …
injury or infection, such as acute lung injury. The objective of this study was to analyze
pulmonary inflammatory responses in young and aged mice after administration of
lipopolysaccharide. Design: Prospective, controlled laboratory study. Setting: Animal
resource facilities and research laboratory. Subjects: Young (2–3 months old) and aged (18–
20 months old) female BALB/c mice. Interventions: Animals received intraperitoneal injection …