Intravitreal injection of endothelin-1 caused optic nerve damage following to ocular hypoperfusion in rabbits
M Sasaoka, T Taniguchi, M Shimazawa, N Ishida… - Experimental eye …, 2006 - Elsevier
The purpose of this study was to investigate the time course of the ocular hypoperfusion,
retinal damage, and optic nerve damage induced by intravitreal injection of endothelin-1 (ET-
1) in rabbits. ET-1, at 5pmol (20μL, twice a week for 2 or 4weeks), was injected from the pars
plana into the posterior vitreous of the right eye. Optic nerve head (ONH) blood flow and
retinal artery diameter, together with the neurofilament light chain (NF-L) content, retinal
morphology, and axon density of the optic nerve, were evaluated at 2, 4, and 8weeks after …
retinal damage, and optic nerve damage induced by intravitreal injection of endothelin-1 (ET-
1) in rabbits. ET-1, at 5pmol (20μL, twice a week for 2 or 4weeks), was injected from the pars
plana into the posterior vitreous of the right eye. Optic nerve head (ONH) blood flow and
retinal artery diameter, together with the neurofilament light chain (NF-L) content, retinal
morphology, and axon density of the optic nerve, were evaluated at 2, 4, and 8weeks after …