High levels of fetal cell-free DNA in maternal serum: a risk factor for spontaneous preterm delivery
OBJECTIVE: This study was conducted to determine whether there is a relationship between
the concentration of fetal cell–free DNA in maternal serum and the duration of pregnancy in
women who are at high risk for preterm delivery because of either preterm labor or preterm
premature rupture of the membranes. STUDY DESIGN: Sera were collected and frozen from
71 women with a male fetus. Maternal serum fetal cell–free DNA concentration was
measured with the use of real-time polymerase chain reaction amplification of DYS1. Fetal …
the concentration of fetal cell–free DNA in maternal serum and the duration of pregnancy in
women who are at high risk for preterm delivery because of either preterm labor or preterm
premature rupture of the membranes. STUDY DESIGN: Sera were collected and frozen from
71 women with a male fetus. Maternal serum fetal cell–free DNA concentration was
measured with the use of real-time polymerase chain reaction amplification of DYS1. Fetal …