[HTML][HTML] Chimerism of murine fetal bone marrow by maternal cells occurs in late gestation and persists into adulthood
AM Marleau, JD Greenwood, Q Wei, B Singh… - Laboratory …, 2003 - Elsevier
Studies of murine severe combined immune-deficient (scid/scid) fetuses gestating in
transgene-tagged immune competent dams have established high frequencies of
transplacental trafficking of nucleated maternal cells. Maternal cells first appeared in thymus
at gestation day (gd) 12.5 and were present in more than 90% of late gestation fetuses.
Morphologically heterogeneous maternal cells were located predominantly in bone marrow
and thymus and also occasionally in liver, spleen, and nonlymphoid organs. We have now …
transgene-tagged immune competent dams have established high frequencies of
transplacental trafficking of nucleated maternal cells. Maternal cells first appeared in thymus
at gestation day (gd) 12.5 and were present in more than 90% of late gestation fetuses.
Morphologically heterogeneous maternal cells were located predominantly in bone marrow
and thymus and also occasionally in liver, spleen, and nonlymphoid organs. We have now …