Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse
PM Brickell, DS Latchman, D Murphy, K Willison… - Nature, 1983 - nature.com
PM Brickell, DS Latchman, D Murphy, K Willison, PWJ Rigby
Nature, 1983•nature.comA cDNA clone corresponding to a mRNA present at elevated levels in transformed
fibroblasts encodes a Qa/Tla class I major histocompatibility complex (MHC) antigen. High
levels of this mRNA are found in all tumour cells tested; the transcript can undergo
alternative splicing; and a repetitive sequence within the transcription unit has the
characteristics of a transposable element. The immunological implications of MHC gene
activation in tumour cells are discussed.
fibroblasts encodes a Qa/Tla class I major histocompatibility complex (MHC) antigen. High
levels of this mRNA are found in all tumour cells tested; the transcript can undergo
alternative splicing; and a repetitive sequence within the transcription unit has the
characteristics of a transposable element. The immunological implications of MHC gene
activation in tumour cells are discussed.
Abstract
A cDNA clone corresponding to a mRNA present at elevated levels in transformed fibroblasts encodes a Qa / Tla class I major histocompatibility complex (MHC) antigen. High levels of this mRNA are found in all tumour cells tested; the transcript can undergo alternative splicing; and a repetitive sequence within the transcription unit has the characteristics of a transposable element. The immunological implications of MHC gene activation in tumour cells are discussed.
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