[HTML][HTML] Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IκB kinase in hepatic macrophages
L Chen, S Xiong, H She, SW Lin, J Wang… - Journal of biological …, 2007 - ASBMB
We recently discovered a novel signaling phenomenon involving a rapid and transient rise
in intracellular low molecular weight iron complex (es) in activation of IκB kinase (IKK) in
hepatic macrophages. We also showed direct treatment with ferrous iron substitutes for this
event to activate IKK. The present study used this model to identify upstream kinases
responsible for IKK activation. IKK activation induced by iron is abrogated by overexpression
of a dominant negative mutant (DN) for transforming growth factor β-activated kinase-1 …
in intracellular low molecular weight iron complex (es) in activation of IκB kinase (IKK) in
hepatic macrophages. We also showed direct treatment with ferrous iron substitutes for this
event to activate IKK. The present study used this model to identify upstream kinases
responsible for IKK activation. IKK activation induced by iron is abrogated by overexpression
of a dominant negative mutant (DN) for transforming growth factor β-activated kinase-1 …