Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers

BS Pukstad, L Ryan, TH Flo, J Stenvik… - Journal of …, 2010 - Elsevier
BACKGROUND: The molecular pathogenesis of chronic skin wounds is complex and not
fully understood. Although these wounds are often characterized as being in a state of
persistent inflammation, the impact and participation of the innate immune responses in
sustaining this inflammation needs further investigation. OBJECTIVE: We investigated the
cytokine profiles, Toll-like receptor (TLR)-stimulating activities and the levels of the
antibacterial peptide Lipocalin-2 (Lcn-2) in a series of healing and non-healing chronic …