A crucial role has been suggested for invariant natural killer T cells (iNKT) in regulating the
development of asthma, a complex and heterogeneous disease characterized by airway
inflammation and airway hyperreactivity (AHR). iNKT cells constitute a unique subset of T
cells responding to endogenous and exogenous lipid antigens, rapidly secreting a large
amount of cytokines, which amplify both innate and adaptive immunity. Herein, we review
recent studies showing a requirement for iNKT cells in various models of asthma in mice and …