[HTML][HTML] Determination of the Consensus Binding Site for MEF2 Expressed in Muscle and Brain Reveals Tissue-specific Sequence Constraints (∗)
V Andrés, M Cervera, V Mahdavi - Journal of Biological Chemistry, 1995 - ASBMB
The myocyte-specific enhancer factor-2 (MEF2) proteins are expressed in the three major
types of muscle (skeletal, cardiac, and smooth) and function as transcriptional activators of
muscle-specific and growth factor-regulated genes through binding to a canonical A/T-rich
cis-element. Although MEF2 proteins are also expressed in brain, MEF2-regulated muscle-
specific gene products are not detected in this tissue. To gain insight into the regulation of
MEF2 function in vivo, we have selected its optimal DNA targets from a library of degenerate …
types of muscle (skeletal, cardiac, and smooth) and function as transcriptional activators of
muscle-specific and growth factor-regulated genes through binding to a canonical A/T-rich
cis-element. Although MEF2 proteins are also expressed in brain, MEF2-regulated muscle-
specific gene products are not detected in this tissue. To gain insight into the regulation of
MEF2 function in vivo, we have selected its optimal DNA targets from a library of degenerate …