[HTML][HTML] Ectopic expression of phospholamban in fast-twitch skeletal muscle alters sarcoplasmic reticulum Ca2+ transport and muscle relaxation
JP Slack, IL Grupp, DG Ferguson, N Rosenthal… - Journal of Biological …, 1997 - ASBMB
There are three isoforms of the sarcoplasmic reticulum Ca 2+-ATPase; they are known as
SERCA1, SERCA2, and SERCA3. Phospholamban is present in tissues that express the
SERCA2 isoform and is an inhibitor of the affinity of SERCA2 for calcium. In vitro
reconstitution and cell culture expression studies have shown that phospholamban can also
regulate SERCA1, the fast-twitch skeletal muscle isoform. To determine whether regulation
of SERCA1 by phospholamban can be of physiological relevance, we generated transgenic …
SERCA1, SERCA2, and SERCA3. Phospholamban is present in tissues that express the
SERCA2 isoform and is an inhibitor of the affinity of SERCA2 for calcium. In vitro
reconstitution and cell culture expression studies have shown that phospholamban can also
regulate SERCA1, the fast-twitch skeletal muscle isoform. To determine whether regulation
of SERCA1 by phospholamban can be of physiological relevance, we generated transgenic …