In vivo studies support the role of trafficking and cytoskeletal-binding motifs in the interaction of MESA with the membrane skeleton of Plasmodium falciparum-infected …
In red blood cells (RBCs) infected with the malaria parasite Plasmodium falciparum, a 19-
residue region of the mature parasite-infected erythrocyte surface antigen (MESA)
associates with RBC cytoskeleton protein 4.1 R; an interaction essential for parasite survival.
This region in MESA is adjacent to a host targeting motif found in other malaria parasite
proteins exported to the membrane skeleton. To demonstrate function of these motifs in vivo,
regions of MESA fused to a reporter were expressed in malaria parasites. Immunochemical …
residue region of the mature parasite-infected erythrocyte surface antigen (MESA)
associates with RBC cytoskeleton protein 4.1 R; an interaction essential for parasite survival.
This region in MESA is adjacent to a host targeting motif found in other malaria parasite
proteins exported to the membrane skeleton. To demonstrate function of these motifs in vivo,
regions of MESA fused to a reporter were expressed in malaria parasites. Immunochemical …