[HTML][HTML] Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1α, HIF-2α, and other pathways
GP Elvidge, L Glenny, RJ Appelhoff, PJ Ratcliffe… - Journal of biological …, 2006 - ASBMB
Studies of gene regulation by oxygen have revealed novel signal pathways that regulate the
hypoxia-inducible factor (HIF) transcriptional system through post-translational hydroxylation
of specific prolyl and asparaginyl residues in HIF-α subunits. These oxygen-sensitive
modifications are catalyzed by members of the 2-oxoglutarate (2-OG) dioxygenase family
(PHD1, PHD2, PHD3, and FIH-1), raising an important question regarding the extent of
involvement of these and other enzymes of the same family in directing the global changes …
hypoxia-inducible factor (HIF) transcriptional system through post-translational hydroxylation
of specific prolyl and asparaginyl residues in HIF-α subunits. These oxygen-sensitive
modifications are catalyzed by members of the 2-oxoglutarate (2-OG) dioxygenase family
(PHD1, PHD2, PHD3, and FIH-1), raising an important question regarding the extent of
involvement of these and other enzymes of the same family in directing the global changes …