[HTML][HTML] An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor α
P Koivunen, P Tiainen, J Hyvärinen… - Journal of Biological …, 2007 - ASBMB
Prolyl 4-hydroxylases (P4Hs) act on collagens (C-P4Hs) and the oxygen-dependent
degradation domains (ODDDs) of hypoxia-inducible factor α subunits (HIF-P4Hs) leading to
degradation of the latter. We report data on a human P4H possessing a transmembrane
domain (P4H-TM). Its gene is also found in zebrafish but not in flies and nematodes. Its
sequence more closely resembles those of the C-P4Hs than the HIF-P4Hs, but it lacks the
peptide substrate-binding domain of the C-P4Hs. P4H-TM levels in cultured cells are …
degradation domains (ODDDs) of hypoxia-inducible factor α subunits (HIF-P4Hs) leading to
degradation of the latter. We report data on a human P4H possessing a transmembrane
domain (P4H-TM). Its gene is also found in zebrafish but not in flies and nematodes. Its
sequence more closely resembles those of the C-P4Hs than the HIF-P4Hs, but it lacks the
peptide substrate-binding domain of the C-P4Hs. P4H-TM levels in cultured cells are …