[HTML][HTML] Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin
JE Digby, E McNeill, OJ Dyar, V Lam, DR Greaves… - Atherosclerosis, 2010 - Elsevier
OBJECTIVE: A major site of action for the atheroprotective drug nicotinic acid (NA) is
adipose tissue, via the G-protein-coupled receptor, GPR109A. Since, adipose tissue is an
active secretory organ that contributes both positively and negatively to systemic
inflammatory processes associated with cardiovascular disease, we hypothesized that NA
would act directly upon adipocytes to alter the expression of pro-inflammatory chemokines,
and the anti-inflammatory adipokine adiponectin. METHODS AND RESULTS: TNF-α …
adipose tissue, via the G-protein-coupled receptor, GPR109A. Since, adipose tissue is an
active secretory organ that contributes both positively and negatively to systemic
inflammatory processes associated with cardiovascular disease, we hypothesized that NA
would act directly upon adipocytes to alter the expression of pro-inflammatory chemokines,
and the anti-inflammatory adipokine adiponectin. METHODS AND RESULTS: TNF-α …