Influence of nicotinic acid, niceritrol and β-pyridylcarbinol on experimental hyperlipidemia and atherosclerosis in mini-pigs

L Lundholm, L Jacobsson, R Brattsand, O Magnusson - Atherosclerosis, 1978 - Elsevier
A study was undertaken to test for suitable conditions for examining the hypolipidemic and
antiatherosclerotic actions of nicotinic acid, niceritrol and β-pyridylcarbinol in
hypercholesterolemic mini-pigs. Hypercholesterolemia was produced in 50 female pigs by
adding 11% dried egg yolk+ 0.5–0.75% cholesterol to their diet for 12–19 months. The
animals were divided into 3 groups according to the response of their initial plasma
cholesterol value (“low”∼ 500;“medium”∼ 700;“high”∼ 1000 mg/100 ml). The plasma …