A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
Cancer research, 2007•AACR
Greater understanding of metastasis is required to improve cancer treatment outcomes.
Recently, changes in expression of the scaffold protein HEF1/CAS-L/NEDD9 were found to
be a potent prometastatic stimulus in melanoma and other cancers. Mechanistic studies
suggest diverse cellular roles of HEF1 and highlight its importance in the response to
extracellular cues that drive invasion and metastasis. As a metastatic “hub” for signaling in
cancer, HEF1 may provide a useful target for drug discovery efforts.[Cancer Res 2007; 67 …
Recently, changes in expression of the scaffold protein HEF1/CAS-L/NEDD9 were found to
be a potent prometastatic stimulus in melanoma and other cancers. Mechanistic studies
suggest diverse cellular roles of HEF1 and highlight its importance in the response to
extracellular cues that drive invasion and metastasis. As a metastatic “hub” for signaling in
cancer, HEF1 may provide a useful target for drug discovery efforts.[Cancer Res 2007; 67 …
Abstract
Greater understanding of metastasis is required to improve cancer treatment outcomes. Recently, changes in expression of the scaffold protein HEF1/CAS-L/NEDD9 were found to be a potent prometastatic stimulus in melanoma and other cancers. Mechanistic studies suggest diverse cellular roles of HEF1 and highlight its importance in the response to extracellular cues that drive invasion and metastasis. As a metastatic “hub” for signaling in cancer, HEF1 may provide a useful target for drug discovery efforts. [Cancer Res 2007;67(19):8975–9]
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