[HTML][HTML] Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function
WH Shen, Z Chen, S Shi, H Chen, W Zhu… - Journal of biological …, 2008 - ASBMB
Mammalian target of rapamycin (mTOR) is a key regulator for cell growth through
modulating components of the translation machinery. Previously, numerous
pharmacological studies using rapamycin suggested that mTOR has an important role in
regulating cardiac hypertrophic growth. To further investigate this assumption, we have
generated two lines of cardiac specific mTOR transgenic mice, kinase-dead (kd) mTOR and
constitutively active (ca) mTOR, using α-myosin heavy chain promoter. α-Myosin heavy …
modulating components of the translation machinery. Previously, numerous
pharmacological studies using rapamycin suggested that mTOR has an important role in
regulating cardiac hypertrophic growth. To further investigate this assumption, we have
generated two lines of cardiac specific mTOR transgenic mice, kinase-dead (kd) mTOR and
constitutively active (ca) mTOR, using α-myosin heavy chain promoter. α-Myosin heavy …