PDGF signaling in cells and mice

M Tallquist, A Kazlauskas - Cytokine & growth factor reviews, 2004 - Elsevier
Since its discovery over three decades ago, platelet-derived growth factor (PDGF) has been
a model system for learning how growth factors regulate biological processes. For the first
several decades investigators used cells grown in tissue culture. More recently, PDGF
signaling has also been investigated in mice. This review outlines the advances in these two
systems, and highlights some of the directions for future investigation.