Insight into the physiological functions of PDGF through genetic studies in mice

C Betsholtz - Cytokine & growth factor reviews, 2004 - Elsevier
Genetic analyses in mice have contributed significantly to the understanding of the
physiological functions of platelet-derived growth factors (PDGFs) and their receptors.
Phenotypic analyses of gene knockouts of PDGF-A, PDGF-B, PDGF alpha-receptors
(PDGFRα) and beta-receptors (PDGFRβ) have shown that these ligands and receptors play
major roles during embryonic development. Conditional and subtle mutations in the same
genes and analysis of chimeric mice have provided additional information about the roles of …