[HTML][HTML] Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator ofCFTR exon 9
E Buratti, FE Baralle - Journal of Biological Chemistry, 2001 - ASBMB
Variations in a polymorphic (TG) m sequence near exon 9 of the human CFTR gene have
been associated with variable proportions of exon skipping and occurrence of disease. We
have recently identified nuclear factor TDP-43 as a novel splicing regulator capable of
binding to this element in the CFTR pre-mRNA and inhibiting recognition of the neighboring
exon. In this study we report the dissection of the RNA binding properties of TDP-43 and
their functional implications in relationship with the splicing process. Our results show that …
been associated with variable proportions of exon skipping and occurrence of disease. We
have recently identified nuclear factor TDP-43 as a novel splicing regulator capable of
binding to this element in the CFTR pre-mRNA and inhibiting recognition of the neighboring
exon. In this study we report the dissection of the RNA binding properties of TDP-43 and
their functional implications in relationship with the splicing process. Our results show that …