[HTML][HTML] TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases
Y Iguchi, M Katsuno, J Niwa, S Yamada, J Sone… - Journal of biological …, 2009 - ASBMB
The 43-kDa TAR DNA-binding protein (TDP-43) is known to be a major component of the
ubiquitinated inclusions characteristic of amyotrophic lateral sclerosis and frontotemporal
lobar degeneration with ubiquitin-positive inclusions. Although TDP-43 is a nuclear protein,
it disappears from the nucleus of affected neurons and glial cells, implicating TDP-43 loss of
function in the pathogenesis of neurodegeneration. Here we show that the knockdown of
TDP-43 in differentiated Neuro-2a cells inhibited neurite outgrowth and induced cell death …
ubiquitinated inclusions characteristic of amyotrophic lateral sclerosis and frontotemporal
lobar degeneration with ubiquitin-positive inclusions. Although TDP-43 is a nuclear protein,
it disappears from the nucleus of affected neurons and glial cells, implicating TDP-43 loss of
function in the pathogenesis of neurodegeneration. Here we show that the knockdown of
TDP-43 in differentiated Neuro-2a cells inhibited neurite outgrowth and induced cell death …