Connexin-mediated cardiac impulse propagation: connexin 30.2 slows atrioventricular conduction in mouse heart
MM Kreuzberg, K Willecke, FF Bukauskas - Trends in cardiovascular …, 2006 - Elsevier
In mouse heart, four connexins (Cxs), Cx30. 2, Cx40, Cx43, and Cx45, form gap junction
(GJ) channels for electric and metabolic cell-to-cell signaling. Extent and pattern of Cx
isoform expression together with cytoarchitecture and excitability of cells determine the
velocity of excitation spread in different regions of the heart. In the SA node, cell–cell
coupling is mediated by Cx30. 2 and Cx45, which form low-conductance (approximately 9
and 32 pS, respectively) GJ channels. In contrast, the working cardiomyocytes of atria and …
(GJ) channels for electric and metabolic cell-to-cell signaling. Extent and pattern of Cx
isoform expression together with cytoarchitecture and excitability of cells determine the
velocity of excitation spread in different regions of the heart. In the SA node, cell–cell
coupling is mediated by Cx30. 2 and Cx45, which form low-conductance (approximately 9
and 32 pS, respectively) GJ channels. In contrast, the working cardiomyocytes of atria and …