Rab GTPases require special machinery for protein prenylation, which include Rab escort
protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab
geranylgeranylation proposes that REP binds Rab and presents it to RGGT. After
geranylgeranylation of Rab C-terminal cysteines, REP delivers the prenylated protein to
membranes. The REP-like protein Rab GDP dissociation inhibitor (RabGDI) then recycles
the prenylated Rab between the membrane and the cytosol. The recent solution of crystal …