Synucleins are a family of small, highly charged proteins expressed predominantly in
neurons. Since their discovery and characterization during the last decade, much has been
learned about their structure, potential functions, interactions with other proteins, and roles in
disease. One of these proteins, α-synuclein (α-syn), is the major building block of
pathological inclusions that characterize many neurodegenerative disorders, including
Parkinson's disease (PD), dementia with Lewy bodies (DLB), and neurodegeneration with …